IgG subclasses pattern and high-avidity antibody to the C-terminal region of merozoite surface protein 1 of Plasmodium vivax in an unstable hypoendemic region in Iran.
Identifieur interne : 001770 ( Main/Exploration ); précédent : 001769; suivant : 001771IgG subclasses pattern and high-avidity antibody to the C-terminal region of merozoite surface protein 1 of Plasmodium vivax in an unstable hypoendemic region in Iran.
Auteurs : Akram Abouie Mehrizi [Iran] ; Sedigheh Zakeri [Iran] ; Ali-Hatef Salmanian [Iran] ; Mohammad Hossein Sanati [Iran] ; Navid Dinparast Djadid [Iran]Source :
- Acta Tropica [ 0001-706X ] ; 2009-10.
English descriptors
Abstract
The C-terminal region of Plasmodium vivax merozoite surface protein 1 (PvMSP-1(19)) is a leading vaccine candidate for inclusion in a polyvalent malaria vaccine. In the present study, the IgG subclasses profile and the avidity of IgG to PvMSP-1(19) were evaluated in individuals (n=94) naturally exposed to P. vivax parasite in malaria endemic areas in Chabahar districts, Iran. In individuals with patent P. vivax malaria, 86.1% was sero-positive to PvMSP-1(19) and IgG1 (81.9%) was the predominant subclass. In addition, to determine the persistence of specific IgG, IgG1 and IgG3 antibodies to PvMSP-1(19), the frequency of antibodies was determined in the infected subjects (n=74) after treatment with standard chloroquine and it was detected that the frequency of responders was significantly reduced to 51.3%, 51% and 16.2%, respectively. The antigen-binding avidity of IgG antibodies to PvMSP-1(19) was measured in sero-positive sera and the high-avidity of IgG, IgG1 and IgG3 was found in 66.6%, 61% and 47% of the infected subjects with P. vivax, respectively. The present result shows that individuals who exposed to vivax malaria in the endemic region in Iran develop antibodies with high-avidity to PvMSP-1(19). These results could help to understand the interactions between the host and P. vivax parasite in development of MSP-1(19)-based vaccine.
Url:
DOI: 10.1016/j.actatropica.2009.05.016
Affiliations:
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Box 1316943551, Tehran</addrLine> <country key="IR"></country> </address> </desc> <listRelation> <relation active="#struct-55944" type="direct"></relation> <relation active="#struct-301247" type="direct"></relation> <relation active="#struct-350881" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-55944" type="direct"><org type="institution" xml:id="struct-55944" status="VALID"> <orgName>Institut Pasteur d'Iran</orgName> <desc> <address> <addrLine>69 avenue Pasteur Téhéran 13164</addrLine> <country key="IR"></country> </address> <ref type="url">http://www.pasteur.ac.ir/</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301247" type="direct"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle><tutelle active="#struct-350881" type="direct"><org type="institution" xml:id="struct-350881" status="INCOMING"> <orgName>Biotechnology Research Center</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Iran</country></affiliation></author></analytic><idno type="DOI">10.1016/j.actatropica.2009.05.016</idno><series><title level="j">Acta Tropica</title><idno type="ISSN">0001-706X</idno><imprint><date type="datePub">2009-10</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Antibody</term><term>Avidity</term><term>C-terminal region of MSP-1</term><term>Immune response</term><term>Malaria</term><term>Plasmodium vivax</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>The C-terminal region of Plasmodium vivax merozoite surface protein 1 (PvMSP-1(19)) is a leading vaccine candidate for inclusion in a polyvalent malaria vaccine. In the present study, the IgG subclasses profile and the avidity of IgG to PvMSP-1(19) were evaluated in individuals (n=94) naturally exposed to P. vivax parasite in malaria endemic areas in Chabahar districts, Iran. In individuals with patent P. vivax malaria, 86.1% was sero-positive to PvMSP-1(19) and IgG1 (81.9%) was the predominant subclass. In addition, to determine the persistence of specific IgG, IgG1 and IgG3 antibodies to PvMSP-1(19), the frequency of antibodies was determined in the infected subjects (n=74) after treatment with standard chloroquine and it was detected that the frequency of responders was significantly reduced to 51.3%, 51% and 16.2%, respectively. The antigen-binding avidity of IgG antibodies to PvMSP-1(19) was measured in sero-positive sera and the high-avidity of IgG, IgG1 and IgG3 was found in 66.6%, 61% and 47% of the infected subjects with P. vivax, respectively. The present result shows that individuals who exposed to vivax malaria in the endemic region in Iran develop antibodies with high-avidity to PvMSP-1(19). These results could help to understand the interactions between the host and P. vivax parasite in development of MSP-1(19)-based vaccine.</p> </div></front></TEI><affiliations><list><country><li>Iran</li></country></list><tree><country name="Iran"><noRegion><name sortKey="Mehrizi, Akram Abouie" sort="Mehrizi, Akram Abouie" uniqKey="Mehrizi A" first="Akram Abouie" last="Mehrizi">Akram Abouie Mehrizi</name></noRegion><name sortKey="Djadid, Navid Dinparast" sort="Djadid, Navid Dinparast" uniqKey="Djadid N" first="Navid Dinparast" last="Djadid">Navid Dinparast Djadid</name><name sortKey="Salmanian, Ali Hatef" sort="Salmanian, Ali Hatef" uniqKey="Salmanian A" first="Ali-Hatef" last="Salmanian">Ali-Hatef Salmanian</name><name sortKey="Sanati, Mohammad Hossein" sort="Sanati, Mohammad Hossein" uniqKey="Sanati M" first="Mohammad Hossein" last="Sanati">Mohammad Hossein Sanati</name><name sortKey="Zakeri, Sedigheh" sort="Zakeri, Sedigheh" uniqKey="Zakeri S" first="Sedigheh" last="Zakeri">Sedigheh Zakeri</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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